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Data Analysis Tools for DNA Microarrays

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Title: Data Analysis Tools for DNA Microarrays
by Sorin Draghici
ISBN: 1-58488-315-4
Publisher: Chapman & Hall
Pub. Date: 04 June, 2003
Format: Paperback
Volumes: 1
List Price(USD): $79.95
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Average Customer Rating: 4.75 (4 reviews)

Customer Reviews

Rating: 5
Summary: Far from superficial...
Comment: When entering the minefields of microarray data analysis, one has to understand and keep up with state-of-the-art technologies and interdisciplinary literatures. A background in molecular biology is clearly not enough to evaluate the pro and cons of the various statistical methods for selecting truly modulated candidate genes in a given experimental biological system. Choosing between the available analysis software's is not an easy task either. Draghici presents a complete visit of the microarray underworld by initiating the reader to all the facettes of this domain. From the fundamentals of slide production and target hybridization to image processing, statistical analysis, experimental design, data management and biological interpretation, all aspects treated herein are described with pertinent details. Draghici slowly, but successfully, tames the reticent molecular biologist to the arid world of statistics and even entertains the reader with anecdotes and humoristic citations.
Clearly written, with appropriate mathematical examples for each topic, this book even includes exercises at the end of some chapters, for the zealous student sleeping in all of us. It constitutes a very good didactic tool and the included CD's allow a good peek in some of the available image/data analysis software's on the market.
As a core facility manager and eternal student, I strongly recommend Draghici's book to life scientists and students who are struggling with statistical analysis and data mining techniques.

Brigitte Malette, Ph. D.
Project Leader, Microarray Platform
Centre for Structural and Functional Genomics
Concordia University
Montreal

Rating: 4
Summary: Detailed and understandable
Comment: Draghici managed to write a manual on applying microarray (data) with a great feeling for explanation of hard issues. The book is relatively easy to read, very complete and covers most, if not all, analysis techniques that are currently around for microarrays.

Highly recommendable!

Rating: 5
Summary: Good Overview of Microarray Technology
Comment: I have had the book for about a month now and I consult it quite frequently. Great coverage of Microarray Data Anlysis. It manages to be thourough without being dry or using excessive jargon. It's very readable and useful for both novices and experienced readers.

It's main strength lies in the use of excellent examples that show the main pitfalls encountered in analyzing microarray data. It has great coverage of statistics and their potential misuse and misunderstanding when they are applied to gene expression data sets. The experimental design section is especially helpful for researchers that are designing a project.

The graphics are excellent and the book is printed on good quality paper.

The book includes two CD's with demo versions of several commercial software packages.

Overall a great buy.

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