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Title: An Introduction to Medicinal Chemistry by Graham L. Patrick ISBN: 0-19-850533-7 Publisher: Oxford Press Pub. Date: April, 2001 Format: Paperback Volumes: 1 List Price(USD): $43.95

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Average Customer Rating: 3.67 (3 reviews)

Rating: 5
Summary: An Excellent Introduction to QSAR
Comment: This text has a very good chapters on QSAR (quantitative-structure activity relationship). I recommend this for the beginning scholars and students interested in QSAR for drug design.

Rating: 4
Summary: A Good Very Basic Look at Medicinal Chemistry
Comment: This book is good in the sense that it is an easy read for anyone interested in the subject. The drawings and cartoons provide a bit of humor to the text and the writing is cloear and focused. The only drawback to the book is that the layperson does not get the full effect of the book without a very good grasp of biochemistry (hence the term layperson!). To get the real scope of the book, one would need to read a good Biochem text ( I personally suggest Lehninger, et. al. Principles of Biochemistry, 3rd ed.). A good pharmacological text would greatly enhance the reader's understanding of the subject as well (i.e. Goodman and Gilman's). Otherwise, the book does give a very brief, very good overview of many aspects of Medicinal Chemistry.

Rating: 2
Summary: The best picture is the one on the cover!.
Comment: The author states that this book is aimed at undergraduates who have a basic grounding in chemistry and are interested in a future career in the pharmaceutical industry. Chemistry background includes now elements of quantum chemistry and molecular orbital theory. The author completely fails in including these elements in the Chapter on Quantitative Structure-Activity Relationships. Moreover, he seems completely unaware of the fundamental contributions of Quantum Chemistry to QSAR. This text could perfectly include elements of (INTRODUCTORY) quantum-chemical applications to QSAR (the scientific literature is full). We must wait until the next edition to get a book that can be recommended to serious students!. Juan S. Gomez-Jeria Associate Professor Faculty of Sciences University of Chile.

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