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Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding

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Title: Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding
by Alan Fersht
ISBN: 0-7167-3268-8
Publisher: W.H. Freeman & Company
Pub. Date: 01 January, 1999
Format: Hardcover
Volumes: 1
List Price(USD): $114.20
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Average Customer Rating: 4.83 (6 reviews)

Customer Reviews

Rating: 5
Summary: Highly recommend it
Comment: Hands down the bible of enzyme kinetics!

Anyone looking to learn more about enzyme kinetics, thermodynamics, structure, and function will find this book clear, thoughtfully written, and at the forefront in the field.

Rating: 5
Summary: essential
Comment: If you are studying protein structure, you probably should read this book for reference.

This is solely my opinion, but I have learned new things and reinforced some old knowledge, as well. The book is well-written, and understandable, without being simplistic.

Some texts are difficult to understand, or dry, or facile. This is not one of those texts.

Rating: 4
Summary: Biochemists Can't Miss
Comment: The book focuses on enzyme catalysis, stereochemistry of enzyme reactions, determination of rate constant, enzyme kinetics, and protein structure and folding. It would be an ideal reference for the study of protein chemistry. It can serve as the primary text for an advanced course in protein chemistry or a supplement for undergraduate biochemistry text.

Protein folding has remained one of the most intricate yet less understood process in modern biochemistry. Feersht's treatise of the subject in this book is splendid. The author overviews protein structure and diversity in the opening chapter. What I find really precious about this book is the discussion on protein engineering, forces on folding, and recombinant DNA technology in the context of protein folding.

Aside from protein chemistry, the chapter on chemical catalysis is excellent in learning more about transition state theory, general acid/base catalysis, covalent catalysis, structure-reactivity relationships, and kinetic isotope effects.

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