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Title: Introduction to Protein Architecture: The Structural Biology of Proteins by Arthur M. Lesk ISBN: 0-19-850474-8 Publisher: Oxford University Press Pub. Date: 2001 Format: Paperback Volumes: 1 List Price(USD): $59.50 |
Average Customer Rating: 5 (2 reviews)
Rating: 5
Summary: A nice introduction to structural biology
Comment: This book deserves 5 stars on the basis of its color stereo diagrams alone! Well done. I wish I had this book when I was starting out as a graduate student! A very good explanation of structural hierarchy. Plus the book also contains excellent details of structure of proteins belonging to specific families -for ex., antibodies. Even today, for my work, I find it very convenient to look into the book first for some structural information rather than into the PDB databases. And yes, I do have a very good pair of stereo glasses always on hand!
Rating: 5
Summary: If Frank Lloyd Wright did proteins...
Comment: This is truly a monument to the architecture of proteins: a gorgeous tour of the structures that dwell within us. The "frozen music" of biology is clearly presented in beautiful detail. The computer-generated renderings give pause to anyone who wonders what God was up to when She thought about creating life. Proteins, as represented here, are Her finest efforts. Visually stunning is only the most obvious aspect of this amazing introduction to structural genomics (proteinomics): the systematic study of protein structures. This is a serious graduate level textbook.
The text should be considered for any introductory graduate level course in biochemistry. Beginning with sound chemical principles, the text lays a solid foundation for the concepts of secondary and tertiary structure within protein. The author builds a superstructure from which to view the motifs of cofactor binding domains and active sites in enzymes.
Each chapter concludes with exercises, problems and "weblems". The weblems underscore the fact that structural genomics, a branch of bioinformatics, is a hot topic in the biotech arena. The weblems ask the reader to pursue ideas on the world wide web. The author provides the reader with a wealth of websites ranging from browser plug-in software for viewing crystal structures, to sources of those structures, to sequence alignment servers which will allow the student to do real research. Well thought-out, the weblems posed are useful to the student in exploring the topics of each chapter.
The author sticks to protein architecture avidly, issues of how proteins fold or how structure might be predicted from amino acid sequence are presented to the reader. It is a credit to the author that he does not speculate on these very hot research topics. The bibiliography for each chapter is current to mid-2000.
A student using this text will have greater insight and understanding of the literature of protein structure, folding, and prediction of structure. This book would also be a useful reference to the veteran practitioner, summarizing an early 21st century look at this field.
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Title: Introduction to Protein Structure by Carl-Ivar Branden, John Tooze ISBN: 0815323050 Publisher: Garland Publishing Pub. Date: 15 January, 1999 List Price(USD): $58.95 |
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Title: Structural Bioinformatics by Philip E. Bourne, Helge Weissig ISBN: 0471201995 Publisher: Wiley-Liss Pub. Date: 07 February, 2003 List Price(USD): $77.50 |
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Title: Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding by Alan Fersht ISBN: 0716732688 Publisher: W H Freeman & Co. Pub. Date: January, 1999 List Price(USD): $111.90 |
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Title: Molecular Modeling and Simulation by Tamar Schlick ISBN: 038795404X Publisher: Springer Verlag Pub. Date: 19 August, 2002 List Price(USD): $84.95 |
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Title: Molecular Modelling: Principles and Applications (2nd Edition) by Andrew R. Leach ISBN: 0582382106 Publisher: Prentice Hall Pub. Date: 30 March, 2001 List Price(USD): $86.00 |
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